Caryophyllene
all about Caryophyllene
Some like it spicy! Cayophyllene is a type of terpene that is known for its distinct spicy aromas that give off a funky warmth to the nose, similar to black pepper, cinnamon and cloves. However, caryophyllene has more going for it than its unique smell.
It is able to up the ante when it comes to our endocannabinoid system as well due to its ability to bind to CB2 receptors – meaning it has a handful of potential medical benefits.

the 411
Quick Facts
Flavors and Aroma
- Caryophyllene is highly concentrated in pepper
- Chewing peppercorns may produce calming effects
- Caryophyllene is often found in foods that may reduce inflammation
- Peppery
- Earthy
May Improve
May Reduce
- Mood
- Relaxation
What Should I Ask For?
What Should I Buy?
Ask your budtender for strains that contain this terpene and smell like:- Pepper
- Spices
- Musk
- Look for strains labeled as indicas or hybrids with mentioned aromas
- Look for a lab report with the percentage of caryophyllene terpene listed in the top three terpenes
Sources:
- Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson’s Disease (nih.gov)
- Molecules | Free Full-Text | Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE) | HTML (mdpi.com)
- Molecules | Free Full-Text | Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE) | HTML (mdpi.com)
- The cannabinoid CB₂ receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain – PubMed (nih.gov)
- β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner – ScienceDirect
- β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway – The American Journal of Pathology (amjpathol.org)
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